Publications

Publication

BOOKS

  • Wang, Y., Lin, D., & Gout, P. W. (2017), Patient-derived Patient-Derived Xenograft Models of Human Cancer. Springer International Publishing.

  • Wang, Y., & Crea, F. (2017), Tumor Dormancy And Recurrence. Springer International Publishing.

 

ORIGINAL ARTICLES

  • Hao J, Ci X, Xue H, Wu R, Dong X, Choi SYC, He H, Wang Y, Zhyang F, Qu S, Zhang F, Haegert AM, Gout PW, Zoubeidi A, Collins C, gleave ME, Lin D, Wang Y. Patient-derived hormone-naive prostate cancer xenograft models reveal growth factor receptor bound protein 10 as an androgen receptor-repressed gene driving the development of castration-resistant prostate cancer. Eur Urol, 2018 Mar 12; S0302-2838(18)30162-3.Full text

  • Ci X, Hao J, Dong X, Choi SYC, Xue H, Wu R, Qu S, Gout PW, Zhang F, Haeger AM, Fazil L, Crea F, Ong CJ, Zoubedi A, He HH, Gleave ME, Collins CC, Lin D, Wang Y. Herterochromatin proteain 1α mediates development and aggressiveness of neuroendocrine prostate cancer. 2018 Feb 27. pii: canres.3677.2017. Full text

  • Qu S, Xue H, Dong X, Lin D, Wu R, Nabavi N, Collins CC, Gleave ME, Gout PW, Wang Y. Aneustat (OMN54) has aerobic glycolysis-inhibitory activity and also immunomodulatory activity as indicated by a first-generation PDX prostate cancer model. Int J Cancer. 2018 Feb 14. doi: 10.1002/ijc.31310. Full text

  • Qu S, Ci X, Xue H, Dong X, Hao J, Lin D, Clermont PL, Wu R, Collins CC, Gout PW, Wang Y. Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancer. Br J Cancer. 2018 Mar 20;118(6):802-812. Full text

  • Liu Y, Ji X, Tong WWL, Askhatova D, Yang T, Cheng H, Wang Y, Shi J. Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1510-1513 Full text

  • Wilkes DC, Sailer V, Xue H, Cheng H, Collins CC, Gleave M, Wang Y, Demichelis F, Beltran H, Rubin MA, Rickman DS. A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents. Cold Spring Harb Mol Case Stud. 2017 Sep;3(5). pii: a001487 Full text.

  • Fornaro L, Vivaldi C, Lin D, Xue H, Falcone A, Wang Y, Crea F, Bootman MD. Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation. PloS One. 2017 Aug 28;12(8):e0182818. Full text

  • Zhang P, Wang D, Zhao Y, Res S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Liy, Lin D, Wang Y, Wang L, Cheng Y, Sun Y, Wang C, Huang H. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017 Sep;23(9):1055-1062.Full text

  • Nabavi N, Saidy NRN, Venalainen E, Haegert A, Parolia A, Xue H, Wang Y, Wu R, Dong X, Collins C, Crea F, Wang Y. miR-100-5p inhibition induces apoptosis in dormant prostate cancer cells and prevents the emergence of castration-resistant prostate cancer. Sci Rep. 2017 Jun 22;7(1):4079. Full text

  • Mo F, Lin D, Takhar M, Ramnarine VR, Dong X, Bell RH, Volik SV, Wang K, Xue H, Wang Y, Haegert A, Anderson S, Brahmbhatt S, Erho N, Wang X, Gout PW, Morris J, Karnes RJ, Den RB, Klein EA, Schaeffer EM, Ross A, Ren S, Sahinalp SC, Li Y, Xu X, Wang J, Wang J, Gleave ME, Davicioni E, Sun Y, Wang Y, Collins CC. Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer. Eur Urol. Epub 2017 Mar 19.  Full text

  • Lin D, Ettinger SL, Qu S, Xue H, Nabavi N, Choi SYC, Bell RH, Mo F, Haegert AM, Gout PW, Fleshner N, Gleave ME, Pollak M, Collins CC, Wang Y. Metabolic heterogeneity signature of primary treatment-naïve prostate cancer. Oncotarget. 2017 Apr 18;8(16):25928-25941.Full text

  • Bishop JL, Thaper D, Vahid S, Davies A, Ketola K, Kuruma H, Jama R, Nip KM, angeles A, Johnson F, wyatt AW, Fazli L, Gleave ME, Lin D, rubin MA, Collins CC, Wang Y, Beltran H, Zoubeidi A. The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer. Cancer Discov. 2017 Jan;7(1):54-71.Full text 

  • Tam KJ, Dalal K, Hsing M, Cheng CW, Khosravi S, Yenki P, Tse C, Peacock JW, Sharma A, Chiang YT, Wang Y,  Cherkasov A, Rennie PS,  Gleave ME, Ong CJ. Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner. Oncotarget. 2017 Feb 7;8(6):9617-9633.  Full text 

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    Nabavi N, Bennewith KL, Churg A, Wang Y, Collins CC, Mutti L. Switching off malignant mesothelioma: exploiting the hypoxic microenvironment. Genes Cancer. 2016 Nov;7(11-12):340-354. Full text 

  • Luk IS, Shrestha R, Xue H, Wang Y, Zhang F, Lin D, Haegert A, Wu R, Dong X, Collins CC, Zoubeidi A, Gleave ME, Gout PW, Wang Y. BIRC6 Targeting as Potential Therapy for Advanced, Enzalutamide-Resistant Prostate Cancer. Clin Cancer Res. 2017 Mar 15;23(6):1542-1551.  Full text 

  • Somasekharan SP, El-Naggar A, Sorensen PH, Wang Y, Cheng H. An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity. Evid Based Complement Alternat Med. 2016;2016:9730654. Full text

  • Li Y, Donmez N, Sahinalp C, Xie N, Wang Y, Xue H, Mo F, Beltran H, Gleave M, Wang Y, Collins C, Dong X SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition. Eur Urol. 2017 Jan;71(1):68-78. doi: 10.1016/j.eururo.2016.04.028. Epub 2016 May 11. Full text

  • Crea F, Venalainen E, Ci X, Cheng H, Pikor L, Parolia A, Xue H, Nur Saidy NR, Lin D, Lam W, Collins C, Wang Y. The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer. Epigenomics. 2016 May;8(5):721-31.

  • Sun X, Clermont PL, Jiao W, Helgason CD, Gout PW, Wang Y, Qu S. Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers. Int J Cancer. 2016 Aug 15;139(4):899-907. Full text

  • Clermont PL, Crea F, Chiang YT, Lin D, Zhang A, Wang JZ, Parolia A, Wu R, Xue H, Wang Y, Ding J, Thu KL, Lam WL, Shah SP, Collins CC, Wang Y, Helgason CD. Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer.Clin Epigenetics. 2016 Feb 12;8:16. Full text

  • Crea F, Quagliata L, Michael A, Liu HH, Frumento P, Azad AA, Xue H, Pikor L, Watahiki A, Morant R, Eppenberger-Castori S, Wang Y, Parolia A, Lennox KA, Lam WL, Gleave M, Chi KN, Pandha H, Wang Y, Helgason CD. Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression. Mol Oncol. 2016 May;10(5):693-703. Full text

  • Chapuy B, Cheng H, Watahiki A, Ducar MD, Tan Y, Chen L, Roemer MG, Ouyang J, Christie AL, Zhang L, Gusenleitner D, Abo RP, Farinha P, von Bonin F, Thorner AR, Sun HH, Gascoyne RD, Pinkus GS, van Hummelen P, Wulf GG, Aster JC, Weinstock DM, Monti S, Rodig SJ, Wang Y, Shipp MA. Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease. Blood. 2016 May 5;127(18):2203-13.  Full text

  • Choi SY, Xue H, Wu R, Fazli L, Lin D, Collins CC, Gleave ME, Gout PW, Wang Y. The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer.Clin Cancer Res. 2016 Jun 1;22(11):2721-33.  Full text

  • Hao J, Chiang YT, Gout PW, Wang Y. Elevated XPO6 expression as a potential prognostic biomarker for prostate cancer recurrence. Front Biosci (Schol Ed). 2016 Jan 1;8:44-55.

  • Fornaro L, Faviana P, De Gregorio V, Vivaldi C, Paolicchi E, Masi G, Loupakis F, Sensi E, Lupi C, Fontanini G, Wang Y, Danesi R, Falcone A, Crea F. Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer. BMC Cancer. 2015 Nov 9;15:874. Full text

  • Crea F, Di Paolo A, Liu HH, Polillo M, Clermont PL, Guerrini F, Ciabatti E, Ricci F, Baratè C, Fontanelli G, Barsotti S, Morganti R, Danesi R, Wang Y, Petrini M, Galimberti S, Helgason CD. Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. Epigenomics. 2015 Aug;7(5):757-65. Full text

  • Akamatsu S, Wyatt AW, Lin D, Lysakowski S, Zhang F, Kim S, Tse C, Wang K, Mo F, Haegert A, Brahmbhatt S, Bell R, Adomat H, Kawai Y, Xue H, Dong X, Fazli L, Tsai H, Lotan TL, Kossai M, Mosquera JM, Rubin MA, Beltran H, Zoubeidi A, Wang Y, Gleave ME, Collins CC. The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer. Cell Rep. 2015 Aug 11;12(6):922-36.  Full text

  • Beltran H, Eng K, Mosquera JM, Sigaras A, Romanel A, Rennert H, Kossai M, Pauli C, Faltas B, Fontugne J, Park K, Banfelder J, Prandi D, Madhukar N, Zhang T, Padilla J, Greco N, McNary TJ, Herrscher E, Wilkes D, MacDonald TY, Xue H, Vacic V, Emde AK, Oschwald D, Tan AY, Chen Z, Collins C, Gleave ME, Wang Y, Chakravarty D, Schiffman M, Kim R, Campagne F, Robinson BD, Nanus DM, Tagawa ST, Xiang JZ, Smogorzewska A, Demichelis F, Rickman DS, Sboner A, Elemento O, Rubin MA. Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response. JAMA Oncol. 2015 Jul;1(4):466-74. dFull text

  • Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt AW, Anderson S, Moskalev I, Haegert A, Alshalalfa M, Erho N, Davicioni E, Fazli L, Li E, Collins C, Wang Y, Black PC. Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015 Aug 28;6(25):21522-32. Full text

  • El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH. Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis. Cancer Cell. 2015 May 11;27(5):682-97. dFull text

  • Clermont PL, Lin D, Crea F, Wu R, Xue H, Wang Y, Thu KL, Lam WL, Collins CC, Wang Y, Helgason CD. Polycomb-mediated silencing in neuroendocrine prostate cancer. Clin Epigenetics. 2015 Apr 3;7:40. Full text

  • Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grunewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, Wang Y, Gleave M, Sorensen PH. YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1. J Cell Biol. 2015 Mar 30;208(7):913-29.  Full text

  • Parolia A, Crea F, Xue H, Wang Y, Mo F, Ramnarine VR, Liu HH, Lin D, Saidy NR, Clermont PL, Cheng H, Collins C, Wang Y, Helgason CD. The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo. Mol Cancer. 2015 Feb 21;14:46. Full text

  • Zhang H, Qi S, Zhang T, Wang A, Liu R, Guo J, Wang Y, Xu Y. miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression. Oncotarget. 2015 Mar 20;6(8):6092-104. Full text

  • Azad AA, Volik SV, Wyatt AW, Haegert A, Le Bihan S, Bell RH, Anderson SA, McConeghy B, Shukin R, Bazov J, Youngren J, Paris P, Thomas G, Small EJ, Wang Y, Gleave ME, Collins CC, Chi KN.Clin Cancer Res. Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer. 2015 May 15;21(10):2315-24.  Full text

  • Yamamoto Y, Loriot Y, Beraldi E, Zhang F, Wyatt AW, Al Nakouzi N, Mo F, Zhou T, Kim Y, Monia BP, MacLeod AR, Fazli L, Wang Y, Collins CC, Zoubeidi A, Gleave M. Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth. Clin Cancer Res. 2015 Apr 1;21(7):1675-87. Full text

  • Lin D, Dong X, Wang K, Wyatt AW, Crea F, Xue H, Wang Y, Wu R, Bell RH, Haegert A, Brahmbhatt S, Hurtado-Coll A, Gout PW, Fazli L, Gleave ME, Collins CC, Wang Y. Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer. Oncotarget. 2015 Jan 30;6(3):1806-20. Full text

  • Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, Nielsen C, Roth AJ, Lefebvre C, Bashashati A, de Souza C, Siu C, Aniba R, Brimhall J, Oloumi A, Osako T, Bruna A, Sandoval JL, Algara T, Greenwood W, Leung K, Cheng H, Xue H, Wang Y, Lin D, Mungall AJ, Moore R, Zhao Y, Lorette J, Nguyen L, Huntsman D, Eaves CJ, Hansen C, Marra MA, Caldas C, Shah SP, Aparicio S. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature. 2015 Feb 19;518(7539):422-6. Full text

  • Hodgson MC, Deryugina EI, Suarez E, Lopez SM, Lin D, Xue H, Gorlov IP, Wang Y, Agoulnik IU. INPP4B suppresses prostate cancer cell invasion. Cell Commun Signal. 2014 Sep 25;12:61.  Full text

  • Wyatt AW, Mo F, Wang K, McConeghy B, Brahmbhatt S, Jong L, Mitchell DM, Johnston RL, Haegert A, Li E, Liew J, Yeung J, Shrestha R, Lapuk AV, McPherson A, Shukin R, Bell RH, Anderson S, Bishop J, Hurtado-Coll A, Xiao H, Chinnaiyan AM, Mehra R, Lin D, Wang Y, Fazli L, Gleave ME, Volik SV, Collins CC. Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer. Genome Biol. 2014 Aug 26;15(8):426. Full text

  • Xie N, Cheng H, Lin D, Liu L, Yang O, Jia L, Fazli L, Gleave ME, Wang Y, Rennie P, Dong X. The expression of glucocorticoid receptor is negatively regulated by active androgen receptor signaling in prostate tumors.Int J Cancer. 2015 Feb 15;136(4):E27-38.  Full text

  • Xie Y, Lu W, Liu S, Yang Q, Carver BS, Li E, Wang Y, Fazli L, Gleave M, Chen Z. Crosstalk between nuclear MET and SOX9/β-catenin correlates with castration-resistant prostate cancer. Mol Endocrinol. 2014 Oct;28(10):1629-39.  Full text

  • Mo F, Wyatt AW, Sun Y, Brahmbhatt S, McConeghy BJ, Wu C, Wang Y, Gleave ME, Volik SV, Collins CC. Systematic identification and characterization of RNA editing in prostate tumors. PLoS One. 2014 Jul 18;9(7):e101431.  Full text

     

  • Sze Ue Iris Luk, Hui Xue, Hongwei Cheng, Dong Lin, Peter W Gout, Ladan Fazli, Colin C Collins, Martin E Gleave, Yuzhuo Wang. The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosis. Oncotarget. 2014 Jul 17. [Epub ahead of print] Full text

  • Anna V Lapuk, Stanislav V Volik, Yuzhuo Wang, Colin C Collins. The role of mRNA splicing in prostate cancer. Asian J Androl. 2014 Jul-Aug;16(4):515-21Full text

  • Yan Ting Chiang, Peter W Gout, Colin C Collins, Yuzhuo Wang. Prostate cancer metastasis‑driving genes: hurdles and potential approaches in their identification. Asian J Androl. 2014 Jul-Aug;16(4):545-8.Full text

  • Dong Lin, Hui Xue, Yuwei Wang, Rebecca Wu, Akira Watahiki, Xin Dong, Hongwei Cheng, Alexander W Wyatt, Colin C Collins, Peter W Gout, Yuzhuo Wang. Next generation patient-derived prostate cancer enograft models. Asian J Androl. 2014 May-Jun;16(3):407-12.Full text

  • Sifeng Qu, Kendric Wang, Hui Xue, Yuwei Wang, Rebecca Wu, Chengfei Liu, Allen C. Gao, Peter W. Gout, Colin C. Collins, Yuzhuo Wang. Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. Mol Oncol. 2014 Mar;8(2):311-22.Full text

  • Dong Lin, Alexander W Wyatt, Hui Xue, Yuwei Wang, Xin Dong, Anne Haegert, Rebecca Wu, Sonal Brahmbhatt, Fan Mo, Lina Jong, Robert H. Bell, Shawn Anderson, Antonio Hurtado-Coll, Ladan Fazli, Manju Sharma, Himisha Beltran, Mark A Rubin, Michael E Cox, Peter W Gout, James Morris, Larry Goldenberg, Stanislav V Volik, Martin E Gleave, Colin C Collins, Yuzhuo Wang. High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development. Cancer Res, 2014 Feb 15;74(4):1272-83Full text

  • Francesco Crea, Akira Watahiki, Luca Quagliata, Hui Xue, Larissa Pikor, Abhijit Parolia, Yuwei Wang, Dong Lin, Wan L Lam, William L Farrar, Takao Isogai, Rudolf Morant, Serenella Castori-Eppenberger, Kim N Chi, Yuzhuo Wang, Cheryl D Helgason. Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget. 2014 Feb 15;5(3):764-74. Full text

  • Yan Ting Chiang, Kendric Wang, Ladan Fazli, Robert Z Qi, Martin E Gleave, Colin C Collins, Peter W Gout, Yuzhuo Wang. GATA2 as a potential metastasis-driving gene in prostate cancer. Oncotarget. 2014 Jan 30;5(2):451-61.Full text

  • Fan Mo, Alexander W Wyatt, Yue Sun, Sonal Brahmbhatt, Brian J McConeghy, Chunxiao Wu, Yuzhuo Wang, Martin E Gleave, Stanislav V Volik, Colin C Collins. Systematic Identification and Characterization of RNA Editing in Prostate Tumors. PLoS One. 2014 Jul 18;9(7):e101431. Full text

  • Chao Zhang, Yik-Shing Kho, Zhe Wang, Yan Ting Chiang, Gary K H Ng, Pang-Chui Shaw, Yuzhuo Wang, Robert Z Qi. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. PLoS One. 2014 Jan 14;9(1):e85206. Full text

  • Francesco Crea, Pier Luc Clermont, Abhijit Parolia, Yuzhuo Wang, Cheryl D Helgason. The non-coding transcriptome as a dynamic regulator of cancer metastasis. Cancer Metastasis Rev. 2013 Dec 18. [Epub ahead of print]Full text

  • Charlotte Svensson, Jens Ceder, Diego Iglesias-Gato, Yin-Choy Chuan, See Tong Pang, Anders Bjartell, Roxana Merino Martinez, Laura Bott, Leszek Helczynski, David Ulmert, Yuzhuo Wang, Yuanjie Niu, Colin Collins, Amilcar Flores-Morales. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer. Nucleic Acids Res. 2014 Jan;42(2):999-1015.Full text

  • Hongtuan Zhang, Can Qi, Andi Wang, Bing Yao, Liang Li, Yuzhuo Wang, Yong Xu. Prognostication of prostate cancer based on NUCB2 protein assessment: NUCB2 in prostate cancer. J Exp Clin Cancer Res. 2013 Oct 16;32:77 Full text

  • Kendric Wang, Yuzhuo Wang, Colin C Collins. Chromoplexy: a new paradigm in genome remodeling and evolution. Asian J Androl. 2013 Nov;15(6):711-2.Full text

  • Hisae Nakamura, Yuwei Wang, Hui Xue, Mark T. Romanish, Dixie L. Mager, Cheryl D. Helgason, and Yuzhuo Wang. Genisteinversus ICI182, 780: AnAllyor Enemy in Metastatic Progression of Prostate Cancer. Prostate. 2013 Dec;73(16):1747-60. Full text

  • Mendoza-Naranjo A1, El-Naggar A, Wai DH, Mistry P, Lazic N, Ayala FR, da Cunha IW, Rodriguez-Viciana P, Cheng H, Tavares Guerreiro Fregnani JH, Reynolds P, Arceci RJ, Nicholson A, Triche TJ, Soares FA, Flanagan AM, Wang YZ, Strauss SJ, Sorensen PH. ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med. 2013 Jul;5(7):1019-34.Full text

  • Yue Yu, Liangliang Liu, Ning Xie, Hui Xue, Ladan Fazli, Ralph Buttyan, Yuzhuo Wang, Martin Gleave, Xuesen Dong. Expression and Function of the Progesterone Receptor in Human Prostate Stroma Provide Novel Insights to Cell Proliferation Control. J Clin Endocrinol Metab. 2013 Jul;98(7):2887-96.Full text

  • Alexander W Wyatt, Fan Mo, Yuzhuo Wang and Colin C Collins. The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing. Asian J Androl. 2013 Mar 18. Full text

  • Christopher G Low, Iris S U Luk, Dong Lin, Ladan Fazli, Kuo Yang, Yong Xu, Martin Gleave, Peter W Gout, Yuzhuo Wang. BIRC6 protein, an inhibitor of apoptosis: role in survival of human prostate cancer cells. PLoS One. 2013;8(2): Epub 2013 Feb 8. Full text

  • Akira Watahiki, Robyn J. Macfarlane, Martin E. Gleave, Francesco Crea, Yuzhuo Wang, Cheryl D. Helgason and Kim N. Chi. Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer. Int J Mol Sci. 2013 Apr 10;14(4):7757-70Full text

  • Daniel T. Johnson, Richard Luong, Suk Hyung Lee, Yue Peng, Atossa Shaltouki, Jane T. Lee, Dong Lin, Yuzhuo Wang and Zhijie Sun. Deletion of Leucine Zipper Tumor Suppressor 2 (Lzts2) Increases Susceptibility to Tumor Development. J Biol Chem. 2013 Feb 8;288(6):3727-38. Full text

  • Xin Dong, Dong Lin, Chris Low, Emily A Vucic, John C. English, John Yee, Nevin Murray, Wan L. Lam, victor Ling, Stephen Lam, Peter W. Gout, Yuzhuo Wang. Elevated Expression of BIRC6 Protein in Non–Small-Cell Lung Cancers is Associated with Cancer Recurrence and Chemoresistance. J Thorac Oncol. 2013 Feb;8(2):161-70. Full text

  • Lei Li, Hongjun Xie, Liang Liang, Ye Gao, Dong Zhang, Xingfa Chen, Xinyang Wang, Luke S Chang, Yuzhuo Wang, Shuyuan Yeh, Dalin He, Chawnshang Chang. Increased PrLZ-mediated androgen receptor transactivation promotes castration resistant prostate cancer growth. Carcinogenesis. 2013 Feb;34(2):257-67.Full text

  • Zhijian Duan, June X Zou, Ping Yang, Yuzhuo Wang, Alexander D Borowsky, Allen C Gao, Hong-Wu Chen.  Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr;73(5):455-66.Full text

  • Daiana D Becker-Santos, Yubin Guo, Mazyar Ghaffari, Elaine D Vickers, Melanie Lehman, Manuel Altamirano-Dimas, Arusha Oloumi, Junya Furukawa, Manju Sharma, Yuzhuo Wang, Shoukat Dedhar, Michael E Cox. Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis. 2012 Dec;33(12):2558-67.Full text

  • Chunxiao Wu, Alexander W Wyatt, Andrew McPherson, Dong Lin, Brian J McConeghy, Fan Mo, Robert Shukin, Anna V Lapuk, Steven J M Jones, Yongjun Zhao, Marco A Marra, Martin E Gleave, Stanislav V Volik, Yuzhuo Wang, S Cenk Sahinalp, Colin C Collins. Poly-gene fusion transcripts and chromothripsis in prostate cancer. Genes Chromosomes Cancer. 2012 Dec;51(12):1144-53.Full text

  • Lapuk AV, Wu C, Wyatt AW, McPherson A, McConeghy BJ, Brahmbhatt S, Mo F, Zoubeidi A, Anderson S, Bell RH, Haegert A, Shukin R, Wang Y, Fazli L, Hurtado-Coll A, Jones EC, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Zhao Y, Marra MA, Fanjul A, Maher CA, Chinnaiyan AM, Rubin MA, Beltran H, Sahinalp SC, Gleave ME, Volik SV, Collins CC. From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer. J Pathol. 2012 Jul;227(3):286-97.Full text

  • Emily A Ricke, Karin Williams, Yi-Fen Lee, Suzana Couto, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha, William A Ricke. Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis. Carcinogenesis. 2012 Jul;33(7):1391-8.Full text

  • Collins CC, Volik SV, Lapuk A, Wang Y, Gout PW, Wu C, Xue H, Cheng H, Haegert A, Bell RH, Brahmbhatt S, Anderson S, Fazli L, Hurtado-Coll A, Rubin MA, Demichelis F, Beltran H, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Gleave ME, Bertino JR, Lubin M, Wang YZ. Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenine Phosphorylase (MTAP), an Exploitable Tumor Target. Mol Cancer Ther. 2012 Jan 17. [Epub ahead of print] Full text

  • Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA. Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov. 2011 Nov;1(6):487-95.Full text

  • Stany MP,  Vathipadiekal V, Ozbun L, Stone RL, Mok S, Xue H, Kagami T, Wang Y, McAlpine JN, Bowtell D,  Gout PW,  Miller DM, Gilks CB, Huntsman DG, Ellard S, Wang YZ, Vivas-Mejia P, Lopez-Berestein G, Sood AK, and Birrer MJ, Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers.PLoS One. 2011;6(7):e21121.Full text

  • Watahiki A, Wang Y, Morris J, Dennis K, O'Dwyer HM, Gleave M, Gout PW, Wang Y. MicroRNAs associated with metastatic prostate cancer. PLoS One. 2011;6(9):e24950. Epub 2011 Sep 30.full text

  • Kuchenbauer F, Mah SM, McPherson A,  Heuser M,  Argiropoulos B, Morin RD,  Berg T, Lai D, Murani, AL Hogge DE,  Ruschmann J,  Starczynowski DT, Karsan A,  O’Connor MD,  Eaves C,  Watahiki A, Wang YZ,  Aparicio SA, Ganser A,  KrauterJ, Johnnidis JB, Marra MA, Carmargo FD and Humphries RK. Comprehensive analysis of mammalian miRNA species and their role in myeloid cells. Blood. 2011 May 31. [Epub ahead of print]full text

  • Hisae Nakamura, Yuwei Wang, Takeshi Kurita, Hans Adomat, Gerald R Cunha, Yuzhuo Wang. Genistein increases Epidermal Growth Factor Receptor signaling and promotes tumor progression in advanced human prostate cancer.  PLoS ONE 6(5): e20034. doi:10.1371/journal.pone.0020034, 2011. full text

  • Iñigo Espinosa, Badreddin Edris, Cheng-Han Lee, Hong Wei Cheng, C Blake Gilks, Yuzhuo Wang, Kelli D Montgomery, Sushama Varma, Rui Li, Robert J Marinelli, Robert B West, Torsten Nielsen, Andrew H Beck, Matt van de Rijn. CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. Am J Pathol. 2011 Oct;179(4):2100-7.full text

  • Ursula Kortmann, Jessica N McAlpine, Hui Xue, Jun Guan, Gavin Ha, Sophie Tully, Sharaz Shafait, Alan Lau, Aaron N Cranston, Mark J O'Connor, David G Huntsman, Yuzhuo Wang, C Blake Gilks. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xneografts. Clinical Cancer Research 2011 Fe 15; 17(4):783-91.Full text

  • Wei-Lin Tung, Yuwei Wang, Peter W Gout, Dean-Mo Liu, Martin Gleave, Yuzhuo Wang. Use of Irinotecan for Treament of Small Cell Carcinoma of the Prostate. The Prostate 14 OCT 2010 Full text

  • Caigan Du, Yuzhuo Wang. The immunoregulatory mechanisms of carcinoma for its survival and development.  J Exp Clin Cancer Res. 2011 Jan 21;30:12 Full text

  • Wency Ip, Olivier Wellman-Labadie, Liren Tang, Mingwan Su, Richard Yu, Jan Dutz, Yuzhuo Wang, Shengquan Huang, Xuejun Zhang, Changzheng Huang, Youwen Zhou. Collagen triple helix repeat containing 1 promotes melanoma cell adhesion and survival. J Cutan Med Surg. 2011 Mar-Apr;15(2):103-10.

  • Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang. Book chapter: Cell biology of prostate cancer and molecular targets. Drug Management of Prostate Cancer. (Figg, W. D.; Chau, C. H.; Small, E. J. Eds.) 2010, 1-24 Full text

  • Hongwei Cheng, Paul W Clarkson, Dongxia Gao, Marina Pacheco, Yuzhuo Wang, Torsten O Nielsen. Therapeutic antibodies targeting CSF1 impede macrophage recruitment in a xenograft model of tenosynovial giant cell tumor. Sarcoma. (2010) Full text

  • Dong Lin, Jane Bayani, Yuwei Wang, Marianne D. Sadar, Maisa Yoshimoto, Peter W. Gout, Jeremy A. Squire, Yuzhuo Wang PhD, Yuzhuo Wang. Development of Metastatic and Non-Metastatic Tumor Lines From a Patient’s Prostate Cancer Specimen - Identification of a Small Subpopulation With Metastatic Potential in the Primary Tumor. Prostate. 2010 Nov 1;70(15):1636-44.Full text

  • Xin Dong, Jun Guan, John C English, Julia Flint, John Yee, Kenneth Evans, Nevin Murray, Calum Macaulay, Raymond T Ng, Peter W Gout, Wan L Lam, Janessa Laskin, Victor Ling, Stephen Lam, Yuzhuo Wang. Patient-derived first generation xenografts of non-small cell lung cancers: Promising tools for predicting drug responses for personalized chemotherapy. Clin. Cancer Research 16:1442-1451, 2010. Full text

  • Helen H L Chiu, Theresa M K Yong, Jun Wang, Yuwei Wang, Robert L Vessella, Takeshi Ueda, Yu-Zhuo Wang, Marianne D Sadar. Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer. Cancer Lett. 2010 Jun 28;292(2):176-85.Full text

  • Lo M, Ling V, Low C, Wang YZ, Gout PW. Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. Current Oncology 17 (3): 9-16, 2010. Full text

  • Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung J. K., Watt K, Tam T, Yang Y.C., Bañuelos C.A., Williams D. E, McEwan I, Wang Y.Z., Sadar MD. Regression of castrate-recurrent prostate cancer by a small molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535–546, 2010. Full text

  • Y Niu, T-M Chang, S Yeh, W-L Ma, Y Z Wang, C Chang. Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails. Oncogene. 2010 Jun 24;29(25):3593-604.Full text

  • McPherson S, Hussain S, Balanathan P, Hedwards S, Niranjan B, Grant M, Chandrasiri U, Toivanen U, Wang YZ, Taylor R, Risbridger G. Estrogen receptor beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen-independent and TNFα-mediated. PNAS 107(7): 3123-3128, 2010. Full text

  • Lu Gan, Shuai Chen, Yuwei Wang, Akira Watahiki, Laura Bohrer, Zhen Sun, Yuzhuo Wang, Haojie Huang. Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer, Cancer Research 69(21):8386-94, 2009. Full text

  • Jun Guan, Maisie Lo, Peter Dockery, Sarah Mahon, Cristina M Karp, Arthur R Buckley, Stephen Lam, Peter W Gout, Yu-Zhuo Wang. The xc- Cystine Transporter as a Therapeutic Target for Small Cell Lung Cancer: Use of Sulfasalazine. Cancer Chemotherapy and Pharmacology, 64(3): 463-72, 2009. Full text

  • Dong Lin, Akira Watahiki, Jane Bayani, Fang Zhang, Lin Liu, Victor Ling, Marianne D Sadar, John English, Ladan Fazli, Alan So, Peter W Gout, Martin Gleave, Jeremy A Squire, Yu-Zhuo Wang. ASAP1, a Gene at 8q24, is Associated with Prostate Cancer Metastasis. Cancer Research. 68: 4352-4359. 2008. Full text

  • M Lo, V Ling, Y Z Wang, P W Gout. The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance. Br J Cancer. 2008 Aug 5;99(3):464-72.Full text

  • Joshua Z Press, Jennifer A Kenyon, Hui Xue, Melinda A Miller, Alessandro De Luca, Dianne M Miller, David G Huntsman, C Blake Gilks, Jessica N McAlpine, Y Z Wang. Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy. Gyn. Oncol. 110: 256-264, 2008. Full text

  • William A Ricke, Stephen J McPherson, Joseph J Bianco, Gerald R Cunha, Yuzhuo Wang, Gail P Risbridger. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha-signaling. The FASEB Journal 22(5):1512-20, 2008. Full text

  • Daniel W Doxsee, Peter W Gout, Takeshi Kurita, Maisie Lo, Arthur R Buckley, Yuwei Wang, Hui Xue, Cristina M Karp, Jean-Claude Cutz, Gerald R Cunha, Yu-Zhuo Wang. Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy. Prostate 67 (2): 162-171, 2007. Full text

  • Meletios Verras, Jane Lee, Hui Xue, Tzu-Huey Li, Yuzhuo Wang, Zijie Sun. The Androgen Receptor Negatively Regulates the Expression of c-Met, Implications for a Novel Mechanism of Prostate Cancer Progression. Cancer Research. 67 (3): 967-975, 2007. Full text

  • K. Al-Romaih, G. R. Somers, J. Bayani, S. Hughes, M. Prasad, J.C. Cutz, H. Xue, M. Zielenska, Y. Z. Wang, J. A Squire. Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation. Cancer Cell International, 7:14doi:10.1186/1475-2867-7-14, 2007. Full text

  • Jean-Claude Cutz, Jun Guan, Jane Bayani, Maisa Yoshimoto, Hui Xue, Margaret Sutcliffe, John English, Julia Flint, Jean LeRiche, John Yee, Jeremy A Squire, Peter W Gout, Stephen Lam, Yu-Zhuo Wang. Establishment in SCID Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression-Related Changes. Clin. Cancer Research. 12 (13): 4043-4054, 2006. Full text

  • William A Ricke, Kenichiro Ishii, Emily A Ricke, Jeff Simko, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha. Steroid Hormones Stimulate Human Prostate Cancer Progression and Metastasis. Int. J. Cancer. 118(9): 2123-2131, 2006. Full text

  • Richard E Sobel, Yuzhuo Wang, Marianne D Sadar. Molecular analysis and characterization of PrEC, commercially available prostate epithelial cells. In Vitro Cell Dev Biol Anim. 2006 Jan-Feb;42(1-2):33-9.Full text

  • Yuwei Wang, Hui Xue, Jean-Claude Cutz, Jane Bayani, Nasrin R Mawji, Wilfred G Chen, Lester J Goetz, Simon W Hayward, Marianne D Sadar, C Blake Gilks, Peter W Gout, Jeremy A Squire, Gerald R Cunha, Yu-Zhuo Wang. An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab. Invest. 85: 1392-1404, 2005 Full text

  • Yuzhuo Wang, Monica P Revelo, Daniel Sudilovsky, Mei Cao, Wilfred G Chen, Lester Goetz, Hui Xue, Marianne Sadar, Scott B Shappell, Gerald R Cunha, Simon W Hayward. Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate 64, 149-159, 2005.Full text

  • Cheng-Han Lee, Hui Xue, Margaret Sutcliffe, Peter W Gout, David G Huntsman, Dianne M Miller, C Blake Gilks, Y Z Wang. Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models. Gyn. Oncol. 96 (1): 48-55, 2005. Full text

  • Manju Sharma, Xiaoyu Li, Yuzhuo Wang, Mark Zarnegar, Chun-Yin Huang, Jorma J Palvimo, Bing Lim, Zijie Sun. A novel PIAS-like protein, hZimp10, acts as the androgen receptor coactivator and forms a complex with SUMO-1 at replication foci. EMBO J. 22 (22): 6101-6114, 2003. Full text

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  • G. R. Cunha, S. W. Hayward, Y.Z. Wang. Role of stroma in carcinogenesis of the prostate. Differentiation. 70 (9-10): 473-85, 2002. Full text

  • Minjung J Kim, Rajula Bhatia-Gaur, Whitney A Banach-Petrosky, Nishita Desai, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha, Robert D Cardiff, Michael M Shen, Cory Abate-Shen. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Research. 62: 2999-3004, 2002. Full text

  • Y. Z. Wang, S. W. Hayward, M. Cao, K. Thayer, G. R. Cunha. Cell differentiation lineage in the prostate. Differentiation 68: 270-279, 2001. Full text

  • Y Wang, D Sudilovsky, B Zhang, P C Haughney, M A Rosen, D S Wu, T J Cunha, R Dahiya, G R Cunha, S W Hayward. A Human Prostatic Epithelial Model of Hormonal Carcinogenesis. Cancer Research. 61: 6064-6072, 2001. Full text

  • S W Hayward, Y Wang, M Cao, Y K Hom, B Zhang, G D Grossfeld, D Sudilovsky, G R Cunha. Malignant Transformation In A Non-Tumorigenic Human Prostatic Epithelial Cell Line. Cancer Research. 61: 8135-8142, 2001. Full text

  • J L Phillips, S W Hayward, Y Wang, J Vasselli, C Pavlovich, H Padilla-Nash, J R Pezullo, B M Ghadimi, G D Grossfeld, A Rivera, W M Linehan, G R Cunha, T Ried. The Consequences of Chromosomal Aneuploidy on Gene Expression Profiles in a Cell Line Model for Prostate Carcinogenesis. Cancer Research. 61: 8143-8149, 2001. Full text

  • T Kurita, Y Z Wang, A A Donjacour, C Zhao, J P Lydon, B W O'Malley, J T Isaacs, R Dahiya, G R Cunha. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ. 2001 Feb;8(2):192-200.Full text

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REVIEW ARTICLES

  • Davies AH, Wang Y, Zoubeidi A. Patient-derived xenografts: A platform for accelerating translational research in prostate cancer. Mol Cell Endocrinol. 2018 Feb 15;462(Pt A):17-24. Full text
  • Lin D, Wang X, Choi SYC, Ci X, Dong X, Wang Y. Immune phenotypes of prostate cancer cells: Evidence of epithelial immune cell-like transition? Asian J Urol. 2016 Oct;3(4):195-202. Full text
  • Wang Y, Wang JX, Xue H, Lin D, Dong X, Gout PW, Gao X, Pang J. Subrenal capsule grafting technology in human cancer modeling and translational cancer research. Differentiation. 2016 Apr-Jun;91(4-5):15-9. Full text
  • Crea F, Nur Saidy NR, Collins CC, Wang Y. The epigenetic/noncoding origin of tumor dormancy.Trends Mol Med. 2015 Apr;21(4):206-11.  Full text
  • Choi SY, Lin D, Gout PW, Collins CC, Xu Y, Wang Y. Lessons from patient-derived xenografts for better in vitro modeling of human cancer. Adv Drug Deliv Rev. 2014 Dec 15;79-80:222-37.  Full text
  • Stephen Yiu Chuen Choi, Colin C Collins, Peter W Gout and Yuzhuo Wang. Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? J Pathol. 2013 Aug;230(4):350-5. Full text
  • Dong Lin, Peter W. Grout, Yuzhuo Wang, Lessons from in-vivo models of castration-resistant prostate cancer, Curr Opin rol. 2013 May;23(3):214-9 Full text
  • Stephen Yiu Chuen Choi, Peter W. Gout, Colin C. Collin, Yuzhuo Wang. Epithelial immune cell-like transition (EIT): A proposed transdifferentiation process underlying immune-suppressive activity of epithelial cancers. Differentiation. 2012 Jun;83(5):293-8. Full text
  • Gout PW, Wang YZ. Drug sensitivity testing for personalized lung cancer therapy. J Thorac Dis 2012 Feb;4(1):17-8. Full text