Drug Resistance Assay• The high take rate of subrenal capsule xenografts enables researchers to readily study tumor behavior (growth/progression/metastasis/acquired drug resistance) of a great variety of precancerous and cancerous diseases in vivo. • Many of our tumor tissue lines have known drug sensitivity/resistance for various cytotoxic drugs acquired from previous studies. • Status of drug-resistance markers in our tumor lines is known, or can be readily screened using tissue microarray or mRNA expression profiles. • Acquired drug resistance can also be established by treating tumor lines with multiple cycles and selecting drug-resistant subpopulations. • Lung cancer and ovarian cancer tumor lines show a variety of responses to standard chemotherapy.
Figure 1. Drug responses in ovarian Living Tumor Lines Figure 2. Drug responses in lung Living Tumor Lines
T/C = average treated tumor mass/average control
tumor mass • Drug resistance lines are being developed via multiple
cycles of standard chemotherapy treatment of selected Living
Tumor lines
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